OUTLINE

Definition

Epidemiology

Classification

Pathogenesis

Clinical features

Investigations

Diagnosis

Complications

Treatment

DIABETES MELLITUS – Definition

Group of metabolic disorders characterized by:

◦Hyperglycaemia due to

◦Deficiencies of Insulin action and/or secretion leading to

◦Disturbances in metabolism of:

Carbohydrate

Fat

Protein

Associated with long term damage, dysfunction and failure of various organs: Eyes, Kidneys, Nerves, Heart & blood vessels

In other words, failure of insulin secretion, action or both lead(s) to rise in blood glucose and other metabolic changes, which if uncorrected cause complications.